Thawing Modes on Stability of Coagulation Control Products after Frozen
10.3969/j.issn.1671-7414.2017.01.035
- VernacularTitle:凝血五项质控血浆低温冷冻后复融方式对其稳定性的影响
- Author:
Yun CAO
;
Xiaoyan ZHANG
;
Deyong CAO
;
Rui ZHANG
;
Tiantian XIN
- Keywords:
coagulation quality control;
freezing and thawing;
stability
- From:
Journal of Modern Laboratory Medicine
2017;32(1):128-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the thawing modes on stability of coagulation control products after frozen,looking for a new theoretical basis for cost control and the quality and safety of laboratory.Methods Using ACL TOP 700 automated co-agulation analyzer and supporting the same batch of reagents and quality control materials conduct of the study:after daily QC,recycled the remaining control materials immediately and dispensed into two EP tubes and frozen at-40℃,respectively thawed by room-temperature and 37℃water bath after 24 hours,and examined together with the date of quality control ma-terial,got 20 pairs of data for analysis the financial impact of two alternate ways on coagulation QC parameters.Results For the room-temperature thawing group,FIB high value increasedby an average 0.23 g/L (t=4.026 9,P<0.05);TT normal value average reduction of 0.46 s (t=-3.813 8,P<0.05),TT high value reduced by an average 0.41s (t=-3.972 8,P<0.05);D-Dimer low-value increased by an average of 14.75 ng/ml FEU (t=2.281 6,P<0.05),while APTT,PT normal and high value,FIB normal value,D-Dimer high value were no significant difference after thawing (P>0.05).For the 37℃water bath group,both normal and high value of APTT,PT,FIB,TT and D-Dimer were no significant difference after tha-wing (P>0.05).Conclusion The commercialization of coagulation control materials can be for the second QC,just follow the principle of rapid after melting and timely detection,other laboratories can be used as a reference.
