Value of urine L-FABP in early diagnosis and progress predicting of acute kidney injury after lung transplantation
10.3969/j.issn.1006-5725.2017.01.07
- VernacularTitle:尿肝型脂肪酸结合蛋白对肺移植术后急性肾损伤的早期诊断及进展判断
- Author:
Caimei CHEN
;
Zhuxing SUN
;
Jing XUE
;
Xiaobin LIU
;
Liang WANG
- Keywords:
Acute kidney injury;
Lung transplantation;
Liver-type fatty acid-binding proteins;
Diagnosis;
Progress
- From:
The Journal of Practical Medicine
2017;33(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of urine liver?type fatty acid?binding proteins(L?FABP) for early diagnosis and progress predicting of acute kidney injury(AKI)after lung transplantation. Methods Urine L?FABP and Scr blood samples in perioperative periods of 119 lung transplant recipients (hospitalized between 2013?2014)were involved in the research. Patients were divided into AKI group and non?AKI group according to KDIGO. Changes in urine L?FABP and Scr of two groups at various time points were recorded. Results Of 119 patients,57 developed AKI after surgery. Urine L?FABP from 0 h to 48 h in the two groups increased significantly, and the difference at 6 h to 48 h between the two groups is significant. In terms of diagnostic value,ROC area of urine L?FABP at 6h is 0.818. When 2254.52 ng/mg Cr was taken as diagnostic dividing line ,sensitivity and specificity was 0.782 and 0.814. In predicting AKI progression ,AUC below AUC of urine L?FABP 0.852. When 4313.17 ng/mgCr was taken as diagnostic dividing line ,sensitivity and specificity was 0.867 and 0.700. Conclusion Urinary L?FABP appears to be a sensitive and specific marker of AKI in lung transplant recipients ,could be a biological marker in the early diagnosis and progression tendency of AKI.
