Preventive effect of puerarin on the formation of deep venous thrombosis of lower extremity after hip surgery in elderly women with osteoporosis
10.3969/j.issn.1006-5725.2017.01.032
- VernacularTitle:葛根素对老年女性骨质疏松髋关节术后下肢深静脉血栓形成的预防作用
- Author:
Xiuli LIU
;
Jifeng ZHANG
;
Yumin SUN
;
Zhiguang XU
;
Yingli WANG
;
Xin WANG
;
Xue HAN
- Keywords:
Osteoporosis;
Puerarin;
Deep vein thrombosis;
Blood rheology
- From:
The Journal of Practical Medicine
2017;33(1):118-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the preventive effects of puerarinon development of deep vein thrombosis (DVT) in elderly women with osteoporosis after hip replacement. Methods 100 elderly women with osteoporosis who scheduled for femoral head arthrolastybetween January 2012 and January 2014 in Cangzhou Central Hospital were selected and then randomly divided into a study group (n=50) and a control group (n=50). The control group received routine anti?inflammatory and anticoagulant therapy ,while the study group received intravenous drip of puerarinof 400 mg mixed with 5%glucose liquid 500 ml daily for 15 days as a treatment course. After the treatment, DVT incidence rate ,change of early diagnostic indexes and hemorheology were compared with their baselines. Results DVT incidence rate was significantly lowerin the study group than in the control group (8.0%vs. 24.0%, P<0.05). Ascompare with the control group,thromboxane A2/prostacyclin,plasma homocysteine and hemorheology?were significantly reduced (P < 0.05). Conclusions Puerarin has a preventive effect for deep vein thrombosis in elderly women with osteoporosis after hip replacement.
