The recent advances in the research of NF-κB in the development and relevant treatment of the colorec-tal cancer
10.11904/j.issn.1002-3070.2017.01.009
- VernacularTitle:NF －κB 对大肠癌发生发展的影响及其相关治疗的研究现状
- Author:
Peiwen DUAN
;
Miaomiao ZHAO
;
Songpo WANG
- Keywords:
NF-KappaB;
Colitis;
Colorectal neoplasm;
Drug resistance
- From:
Practical Oncology Journal
2017;31(1):43-47
- CountryChina
- Language:Chinese
-
Abstract:
In eukaryotic cells ,NF-κB transcription factor family regulates many processes like cell sur-vival,growth,and apoptosis.It participates in the development of a variety of diseases ,including inflammatory,im-mune disease ,and cancer .As an inflammatory factor , NF-κB mediates the transformation of chronic colitis to cancer during the course of colorectal cancer .Furthermore,it could inhibit cell apoptosis through regulating cell cycles,which promotes the development of colorectal cancer and mediates the multidrug resistance of the tumor cells.Therefore,targeting NF-κB,a large number of preparations involved both Chinese and western medicine has been researched .The further research and the use of them may be an effective method to cure the colorectal cancer in clinical work .
