Mechanisms involved in liver metastasis of breast cancer
10.11904/j.issn.1002-3070.2017.01.010
- VernacularTitle:乳腺癌肝转移机制研究进展
- Author:
Bo LI
;
Xuesong CHEN
- Keywords:
Breast cancer;
Liver metastasis;
Micro-environment
- From:
Practical Oncology Journal
2017;31(1):48-52
- CountryChina
- Language:Chinese
-
Abstract:
Liver is the common metastatic site of breast cancer .The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver micro -environment .In this re-view,we reviewed the molecular(including the connection of proteins ,protein kinases,miRNAs),signal transduc-tion pathways(including CXCL12-CXCR4 axis,Wnt/beta-catenin signaling pathway,AF1q/TCF7/CD44 regu-latory axis,laminin receptor/Akt/ERK signaling pathway,leptin/ERK/IL-8 signaling pathway)and the influen-cing factors(including hypoxia inducible factors,tumor-associated fibroblasts,adipose tissue matrix stem cells, metalloproteinases,selective ligands,inflammatory cell infiltration)associated with the liver micro -environment in breast cancer .
