The transcription factor X-box binding protein-1 in tumorigenesis and development of cancer
10.11904/j.issn.1002-3070.2017.01.014
- VernacularTitle:XBP －1在肿瘤发生发展中的研究进展
- Author:
Shouhua NI
;
Xiaolong YUE
;
Jin WU
- Keywords:
XBP-1;
Immune escape;
Angiogenesis;
Cancer
- From:
Practical Oncology Journal
2017;31(1):65-68
- CountryChina
- Language:Chinese
-
Abstract:
X-box binding protein -1(XBP-1)is a newly found protein that plays significant roles in protein folding and endoplasmic reticulum construction .The expression of XBP-1 is widely displayed in various kinds of tumor and is shown to take part in tumorigenesis and tumor progression .This review briefly summarizes the biology of XBP-1 and focuses on recent findings concerning its role in immune evasion ,tumorigenesis ,devel-opment of cancer ,angiogenesis ,hypoxia ,invasion and metastasis .
