Research progress in epigenetic aberrant in classic Hodgkin lymphoma
10.11904/j.issn.1002-3070.2017.01.016
- VernacularTitle:经典型霍奇金淋巴瘤表观遗传学异常及其对免疫逃逸的影响
- Author:
Xiaojian LIU
;
Zhiguo LONG
;
Zhongjie QIAO
- Keywords:
Classical Hodgkin lymphoma;
Methylation;
Acetylation;
Immune escape;
Immune checkpoint inhibitor
- From:
Practical Oncology Journal
2017;31(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
The malignant phenotype of classical Hodgkin lymphoma ( cHL) is partly maintained by epige-netic aberrant ,of which consisted mainly abnormal histone methylation and deacetylation .Progress has been made in clinical trials related to the histone deacetylases inhibitors ( HDACis) in cHL.There is a close association noted between the epigenetic aberrants and the immune escape in cHL .DNA methyltransferase ( DNMT) inhibitors, HDACis and immune checkpoint blockade have shown synergistic effects .Further study to improve the cure rate in cHL by combination strategy is of significant importance .
