The research progress in transfusion-related iron overload in hematological malignancies
10.11904/j.issn.1002-3070.2017.01.017
- VernacularTitle:输血相关性铁过载在血液肿瘤中的研究进展
- Author:
Yaru DU
;
Yanhong ZHAO
;
Jin ZHOU
- Keywords:
Transfusion -related iron overload;
Myelodysplastic syndrome;
Hematopoietic stem cell transplantation;
Prognosis
- From:
Practical Oncology Journal
2017;31(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Transfusion -related iron overload damage iron homeostasis of organism ,which damages the structure of the vital organs and leads to the dysfunction of important organs .Iron overload affects the prognosis of the patients,which promotes myelodysplastic syndrome transformation to acute leukemia and reduces the total sur -vival rate of patients with hematopoietic stem cell transplantation ,which increases the treatment related mortality after hematopoietic stem cell transplantation and increases the chance of infection .Iron depletion therapy can de-lay the progression of acute leukemia and prolong the survival time of the patients with acute leukemia and show a certain anti-proliferative activity .
