Progress in the mechanisms of keratoacanthoma regression
10.11904/j.issn.1002-3070.2017.01.018
- VernacularTitle:角化棘皮瘤消退机制的研究进展
- Author:
Bingmei LIU
;
Xue CHENG
;
Ronggui XING
;
Jing YANG
- Keywords:
Keratoacanthoma;
Hair follicles cycle;
Apoptosis;
Immunity
- From:
Practical Oncology Journal
2017;31(1):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Keratoacanthoma ( KA) is an epithelial neoplasm occurring in sun -exposed skin of the elder-ly.Two striking features of KA are its clinical behavior with spontaneous regression after rapid growth and its nos -ological position on the border between benignity and malignancy .The regression of KA may be associated with the hair follicle cycle,apoptosis and immune function of organism .This article summarizes physiological mecha-nisms such as Wnt/retinoic acid signalling cross -talk,the function of p53,bcl-2,bcl-xL and bak in apopto-sis,and the mechanism of action of several immune -related cells,that drives KA regression .It can provide theo-retical basis for us to select the method as well as time of the treatment in KA .
