Clinical features and prognosis of 25 cases of soft tissue sarcoma with soft tissue me-tastasis

VernacularTitle:软组织肉瘤远隔软组织转移25例临床病理特点及预后分析
Author: Tian GAO ; Zhengfu FAN ; Jiayong LIU ; Chujie BAI ; Ruifeng XUE ; Shu LI ; Lu ZHANG ; Zhiwei FANG
Keywords: soft tissue sarcoma; soft tissue metastasis; lung metastasis; synchronous metastasis; metachronous metastasis
From: Chinese Journal of Clinical Oncology 2017;44(1):36-40
CountryChina
Language:Chinese
Abstract: Objective:To explore the outcome of soft tissue sarcoma (STS) on patients with soft tissue metastasis. Methods:We ana-lyzed 25 STS patients with soft tissue metastasis primarily localized on extremity and trunk. The study was conducted from June 2010 to June 2016 by retrospective analysis of the clinical and pathological characteristics of the patients. The assessed endpoints were overall survival. Results:Six patients (24%) had synchronous soft tissue metastasis, and 19 patients (76%) had metachronous metasta-sis. The average time for primary tumor recession of metastatic lesions was 45.3 months. Metastases were most common in parts of the trunk in 18 patients (72%), followed by the head and neck in 5 patients (20%). Eleven patients (44%) with lung metastasis had poor prognosis. Conclusion:STS occurred more rarely in soft tissue metastasis than in pulmonary metastasis. Neoadjuvant chemotherapy and surgical treatment were the major therapies employed. Targeted therapy as a new treatment rendered good results.