Advances in molecular targeted therapy for soft tissue sarcomas

VernacularTitle:软组织肉瘤分子靶向治疗研究进展
Author: Tian GAO ; Zhengfu FAN ; Zhiwei FANG
Keywords: soft tissue sarcoma; targeted therapy; precision medicine; pazopanib; PD-1 antibody
From: Chinese Journal of Clinical Oncology 2017;44(1):7-13
CountryChina
Language:Chinese
Abstract: Sarcomas are tumors of mesenchymal origin that account for approximately 1%of human cancers. There are at least 60 dif-ferent subtypes of soft tissue sarcoma (STS). However, most tumor types are highly malignant tumors that lack an optimal therapeutic agent. Although gastrointestinal stromal tumor (GIST) responds well to imatinib, other types of STSs remain challenging because of their heterogeneous genetic and clinical features and poor prognosis. In recent years, the field of molecular targeted therapy has pro-gressed rapidly. Patients with advanced disease can receive individualized treatment to improve their quality of life. This review focus-es on the targeted therapies that have been evaluated for advanced non-GIST STS. Other promising novel therapeutic agents that are currently in the early phases of investigation are also presented.