Effect of compound raspberry seed powder on acute radiation injury
10.3760/cma.j.issn.0254-5098.2017.01.005
- VernacularTitle:复方树莓籽粉对急性放射性损伤作用的研究
- Author:
Zhenzhen WANG
;
Haitao WANG
;
Guangkai GAO
;
Hao CHEN
;
Bin WANG
- Keywords:
Compound raspberry seed powder;
X-rays;
Radiation injury;
Superoxide dismutase;
Glutathione peroxidase
- From:
Chinese Journal of Radiological Medicine and Protection
2017;37(1):24-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of compound raspberry seed powder on acute irradiated rat .Methods Totally forty Wistar rats were randomized divided into four groups:normal control group, radiation group, vitamin group, compound raspberry seed powder group . The drugs were intragastrically administrated for 7 days.On 8th day, the rats in each group except control were irradiated with 8 Gy X-rays.24 h after irradiation, all rats were sacrificed and its WBC, PLT, superoxide dismutases (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-PX) in serum were detected, the DNA damage in peripheral blood lymphocytes ( PBL ) was measured with the single cell gel electrophoresis technique.Results Compared with radiation alone group , the quantities of WBC, PLT, the activity of SOD, the content of MDA and the activity of GSH-PX in the vitamin group and compound raspberry seed powder group were significantly improved(F=14.869, 6.376, 7.705, 3.851, 3.134, P<0.05).The DNA damage in PBL of radiation alone group was more severe than that of other three groups ( F=5.493, P<0.05) .Conclusions Raspberry seed powder is effective in radiation protection .
