Epidemiology investigation on capillary leakage syndrome in critically ill newborns
10.3760/cma.j.issn.1673-4912.2017.01.014
- VernacularTitle:危重症新生儿毛细血管渗漏综合征的临床流行病学调查
- Author:
Lijuan SHENG
;
Haiyan ZHAO
;
Yue DING
;
Weimin HUANG
- Keywords:
Capillary leakage syndrome;
Epidemiology;
Critically ill;
Infant,newborn
- From:
Chinese Pediatric Emergency Medicine
2017;24(1):65-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of capillary leakage syndrome ( CLS ) occurring in critically ill newborns in Guangzhou. Methods Three tertiary hospitals in Guangzhou were chosen as research field;critically ill newborns with diagnosis as CLS in NICU of three hospitals were retro-spectively studied from January 2011 to December 2015; and the morbidity,mortality,causes,treatment and outcome of CLS neonates were analyzed. Results There were 49 cases diagnosed as CLS, accounting for 1. 62%(49/3 029)of the total number of critically ill newborns admitted to NICUs in the same period. The common primary factors were preterm low birth weight(34 cases,69. 4%),respiratory distress syndrome(38 cases,77. 5%),congenital anomaly(19 cases,38. 8%),asphyxia(17 cases,34. 7%),and intrauterine infec-tion(12 cases,24. 5%). The 83. 7%(41/49) of CLS occurred within 72 hours after admission. The overall mortality of CLS was 30. 6%( 15/49 ) . The main lethal cause was multiple organ dysfunction syndrome (60. 0%,9/15). Treatment included antibiotics,vasoactive drugs,fluid resuscitation,corticosteroids,and me-chanical ventilation. Conclusion CLS is a common critical illness in NICU with high mortality and poor prognosis. Early prediction and early intervention could improve survival and prognosis in critically ill neonates with CLS.
