Calcium-sensing receptor diseases and their molecular pathogenesis

VernacularTitle:钙敏感受体疾病及其分子发病机制
Author: Chang SHAN ; Lei YE ; Jianmin LIU
Keywords: Calcium-sensing receptor; Parathyroid; Bone; Kidney; G protein
From: Chinese Journal of Endocrinology and Metabolism 2017;33(1):78-84
CountryChina
Language:Chinese
Abstract: [Summary] Extracellular calcium is essential for the regulation of a variety of biological processes. Calcium-sensing receptor (CaSR) plays a central role in maintaining Ca2+ homeostasis, while G-protein α-11 (Gα11 ) subunit and adaptor-related protein complex 2 sigma (AP2σ) are also involved in CaSR signaling transduction. Loss- or gain-of-function mutations of these encoding genes cause different types of familial hypocalciuric hypercalcaemia (FHH) and autosomal dominant hypocalcaemia (ADH). Calcimimetic and calcilytic drugs are useful in treating these FHH and ADH disorders. The current paper is a Chinese translation of a review entitled as “Disorder of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis” published in 《 Journal of Molecular Endocrinology》(2016,57:R127-R142) with the permission from the author and the journal.