Expressions of metadherin and cyclinD1 in esophageal squamous cell carcinoma and their clinical significances
10.3760/cma.j.issn.1006-9801.2017.01.005
- VernacularTitle:食管鳞状细胞癌中异黏蛋白和细胞周期蛋白D1的表达及其临床意义
- Author:
Xuanqin YANG
;
Xiaojuan WANG
;
Peng BU
;
Yuanyuan ZHAO
;
Enwei XU
- Keywords:
Esophageal neoplasms;
Carcinoma,squamous cell;
Metadherin;
CyclinD1
- From:
Cancer Research and Clinic
2017;29(1):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of metadherin (MTDH) and cyclinD1 in esophageal squamous cell carcinoma (ESCC) and their clinical significances. Methods The protein expressions of MTDH and cyclinD1 were detected by immunohistochemistry in 78 cases of ESCC. Results The positive expression rate of MTDH in ESCC was 71.79%(56/78) and the positive expression rate of cyclinD1 in ESCC was 74.36%(58/78). The expressions of MTDH and cyclinD1 were significantly correlated with the degree of differentiation and lymph node metastasis (both P< 0.05), but not with the age, gender of patients and depth of tumor invasion (all P> 0.05). Conclusion The over expressions of MTDH and cyclinD1 protein may involve in the occurrence and development of esophageal carcinoma, which play important roles in the invasion and metastasis of esophageal cancer.
