Roles and mechanisms of early blood-brain barrier damage in hemorrhagic transformation in acute ischemic stroke after tPA thrombolysis
10.3760/cma.j.issn.1673-4165.2016.11.010
- VernacularTitle:早期血脑屏障损伤在急性缺血性卒中 tP A溶栓后出血性转化中的作用及其机制
- Author:
Ting WANG
;
Ke YANG
;
Yuan ZHANG
- Keywords:
Stroke;
Brain Ischemia;
Cerebral Hemorrhage;
Blood-Brain Barrier;
Tissue Plasminogen Activator;
Thrombolytic Therapy
- From:
International Journal of Cerebrovascular Diseases
2016;24(11):1033-1038
- CountryChina
- Language:Chinese
-
Abstract:
Hemorrhagic transformation(HT) is the most severe complication after tissue-type plasminogen activator (tPA) thrombolysis. It greatly limits the clinical application of tPA. Early blood-brain barrier ( BBB) damage may be an important mechanism for HT. Maintaining the integrity of BBB can significantly decrease the risk of HT. This article review s the roles, mechanisms, and preventive measure of early BBB damage in HT after tPA thrombolysis.
