Aquaporin 4 and cerebrovascular disease
10.3760/cma.j.issn.1673-4165.2016.11.013
- VernacularTitle:水通道蛋白4与脑血管病
- Author:
Jing DONG
;
Heling CHU
;
Zidan GAO
;
Yuping TANG
;
Qiang DONG
- Keywords:
Brain Ischemia;
Cerebral Hemorrhage;
Aquaporin 4;
Brain Edema;
Blood-Brain Barrier;
Astrocytes
- From:
International Journal of Cerebrovascular Diseases
2016;24(11):1050-1054
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporin4(AQP4),a member of the aquaporin family,is mainly expressed inastrocytes end-feet in the central nervous system. A large number of experimental studies have show n that AQP4 expression plays an important role in the occurrence, development, and regression of brain edema after different types of stroke. In addition, the AQP4 expression can affect the development process of cerebrovascular disease through the mechanisms such as affecting the integrity of the blood-brain barrier and promoting astrocyte migration, nerve regeneration, and neuroinflammatory response. Investigation of regulation mechanisms of AQP4 in transmembrane transport of substance in brain and intracel ular and extracel ular environmental balance and its expression in model of cerebrovascular disease have an important significance for understanding the occurrence, development, protection, and treatment of clinical cerebrovascular disease.
