Application of Precise Intracoronary Retrograde Thrombolysis During Primary PCI in Patients With Acute ST-segment Elevation Myocardial Infarction
10.3969/j.issn.1000-3614.2016.12.004
- VernacularTitle:冠状动脉内逆向精确溶栓术在急性ST段抬高型心肌梗死患者行直接经皮冠状动脉介入治疗中应用的研究
- Author:
Jingguo NONG
;
Jinwen TIAN
;
Liang PENG
;
Ya HUANG
;
Mohan LIU
;
Ting SUN
;
Wenbin SHEN
;
Zhe TANG
;
Lifeng LIU
;
Yu ZHAO
;
Qingyan LIU
;
Jing BAI
;
Yu WANG
- Keywords:
Myocardial infarction;
Angioplasty,transluminal,percuteanous coronary;
Thrombolysis
- From:
Chinese Circulation Journal
2016;31(12):1160-1164
- CountryChina
- Language:Chinese
-
Abstract:
Objective: In comparison with thrombus aspiration, to study the safety and effcacy of precise intracoronary retrograde thrombolysis during primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI).
Methods: A total of 123 consecutive patients with acute STEMI received primary PCI in our hospital from 2014-01 to 2015-12 were enrolled.The patients were randomly divided into 2 groups: RT group, the patients received precise intracoronary retrograde thrombolysis (RT),n=60 and TA group, the patients received thrombus aspiration (TA),n=63, among them, 3 patients with failed TA were excluded. Primary end points included occurrence rates of no-lfow after PCI and ST-segment resolution (STR)≥50% at (60-90) min after PCI; primary safety end points included occurrence rates of in-hospital stroke and TIMI-hemorrhage events.
Results:①Compared with TA group, RT group showed decreased no-lfow rate after PCI (1.7% vs 15.0%),P=0.008 and increased rate of STR≥50% after PCI (65.0% vs 45.0%),P=0.028, improved LVEF by echocardiography (50.7±8.6) % vs (46.7±8.3)%,P=0.011. The in-hospital MACE occurrence rate was similar between 2 groups,P>0.05.②No in-hospital stroke or TIMI-hemorrhage events occurred in neither group.
Conclusion: Intracoronary retrograde precise thrombolysis had the similar safety to thrombus aspiration during primary PCI in patients with acute STEMI, it may reduce no-relfow rate and improve left ventricular function after PCI.
