Impact of Acute Myocardial Infarction Concurrent Acute Kidney Injury on Major Adverse Cardiac Events Occurrence During Hospitalization
10.3969/j.issn.1000-3614.2016.12.005
- VernacularTitle:急性心肌梗死并发的急性肾损伤对患者住院期间发生主要不良心脏事件的影响
- Author:
Zongqun CAI
;
Shunqi GUO
;
Qinggao LIAO
- Keywords:
Myocardial infarction;
Kidney injury;
Major adverse cardiac events
- From:
Chinese Circulation Journal
2016;31(12):1165-1169
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the impact of acute myocardial infarction (AMI) concurrent acute kidney injury (AKI) on major adverse cardiac events (MACE) occurrence during hospitalization.
Methods: A total of 625 AMI patients treated in our hospital from 2011-01 to 2014-03 were retrospectively studied. According to AKI incidence, the patients were divided into 2 groups: AKI group,n=86 and Non-AKI group,n=539. Based on AKI network (AKIN) criteria, AKI group was further divided into 3 subgroups as AKI-I subgroup,n=45, AKI-II subgroup,n=27, AKI-III subgroup,n=14; based on renal function at admission, AKI group was divided into another set of 2 subgroups as Normal renal function subgroup [(eGFR≥90 ml/(min·1.73m2)],n=61 and Renal dysfunction subgroup [(eGFR<90/(min·1.73m2)],n=25. The incidence of MACE was compared among different groups and the risk factors for MACE occurrence in AMI patients during hospitalization were studied by multivariate Logistic regression analysis.
Results: The incidences of MACE in AKI group and Non-AKI group was (59.3% vs 16.9%),P<0.05; in Normal renal function subgroup and Renal dysfunction subgroup was (59% vs 60%),P>0.05. Multivariate Logistic regression analysis showed that AKI was the independent risk factor for MACE occurrence in AMI patients; elevated AKI stages were accompanied with the higher incidence of MACE accordingly, compared with AKI-I subgroup, the incidences of MACE in AKI-III subgroup and AKI-II subgroup were as (OR=1.68, 95% CI 1.14-1.69),P<0.05 and (OR=2.01, 95% CI 1.35-1.84), P<0.05 respectively.
Conclusion: AKI was closely related to MACE occurrence in AMI patients, effectively preventing AKI may improve the prognosis in relevant patients.
