Relationship among lipoprotein-associated phospholipase A 2 gene A379V and T403V locus polymor-phisms and coronary heart disease
10.3969/j.issn.1008-0074.2016.06.03
- VernacularTitle:脂蛋白相关磷脂酶 A2基因 A379V和 T403C 位点多态性与冠心病的关系研究
- Author:
Saimei LIN
;
Li LAI
;
Huazhen LU
;
Xiaoli SHEN
;
Dian CHEN
;
Yaocheng WANG
;
Hong YU
;
Shanglong LIU
- Keywords:
Phospholipases;
Polymorphism,single nucleotide;
Coronary disease
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2016;25(6):568-573
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship among lipoprotein‐associated phospholipase A2 (Lp‐PLA2 ) gene A379V and T403V locus polymorphisms and genetic susceptibility of coronary heart disease (CHD) .Methods:Lp‐PLA2 gene A379V and T403V locus polymorphisms of 160 coronary angiography confirmed CHD patients (CHD group ) and 117 healthy subjects (healthy control group ) were measured using gene sequencing technique .ELISA was used to measure blood lipids and plasma Lp‐PLA2 level in two groups ,and they were compared between two groups . Results:Compared with healthy control group ,there were significant rise in age ,male proportion ,plasma levels of hs‐cTnI ,hsCRP ,TC ,LDL‐C , Lp (a) ,WBC ,mononuclear cells (MNCs) and Lp‐PLA2 [ (119.98 ± 49.41) ng/ml vs .(248.59 ± 76.51) ng/ml] ,and significant reduction in HDL‐C level in CHD group ( P<0.01 all) .The CC , CT , TT genotype and C , T allele were de‐tected all in A379V and T403C locus of two groups .Compared with healthy control group ,there were significant rise in frequencies of CC genotype (1.7% vs .9.3% ) and C allele (13.7% vs .20.3% ) of Lp‐PLA2 gene T403C locus in CHD group , P< 0.05 both . All genotypes and alleles of A379V locus possessed no significant difference between CHD and healthy control group . Conclusion:Plasma Lp‐PLA2 level may be related to CHD risk .Lp‐PLA2 gene T403C locus poly‐morphism possesses certain relationship with genetic susceptibility of CHD .
