The research progresses in USP22 in malignant tumors
10.11904/j.issn.1002-3070.2016.06.015
- VernacularTitle:USP22在恶性肿瘤中的研究进展
- Author:
Jijun WANG
;
Yan HE
- Keywords:
Malignant tumor;
Overexpression;
USP22
- From:
Practical Oncology Journal
2016;30(6):551-554
- CountryChina
- Language:Chinese
-
Abstract:
Deubiquitylases remove ubiquitin moieties from different substrates to regulate protein activity and cell homeostasis .Since this posttranslational modification plays a role in several different cellular functions ,its deregulation has been associated with different pathologies .Aberrant expression of Ubiquitin -Specific Peptidase 22(USP22)has been associated with poor cancer prognosis .This article reviews the research status of USP 22.
