Research progress of CD4 +CD25 +Foxp3 +regulatory T cells in tumor immunosuppressive microenviron-ment
10.11904/j.issn.1002-3070.2016.06.016
- VernacularTitle:CD4＋CD25＋Foxp3＋Treg细胞调控肿瘤免疫抑制微环境的研究进展
- Author:
Jiaqi LIU
;
Yaohua LIU
;
Xin CHEN
;
Shiguang ZHAO
- Keywords:
Regulatory T cell;
Tumor escape;
Immunosuppression microenvironment
- From:
Practical Oncology Journal
2016;30(6):555-559
- CountryChina
- Language:Chinese
-
Abstract:
CD4 +CD25 +Foxp3 +regulatory T cells(Tregs)are essential for tumor immunosuppressive mi-croenvironment and secrete some inhibitory cytokines IL -10,IL-35,TGF-β1 and FGL2 which are key media-tors of Treg immunosuppressive function .Tregs have been shown to be important contributors to the tumor escape immunosurveillance and play a critical role in the induction of suppression to CD 4 +T,CD8 +T and NK cell,and suppression of specific anti -tumor immunity .Further research of the role of Tregs in tumor immunosuppressive microenvironment is important to understand malignant tumor pathogenetic and immunological therapeutics .In ad-dition,Tregs and inhibitory cytokines become more critical for clinical applications ,prognosis evaluation and ther-apies.
