Changes of adrenal cortical function in children with growth hormone deficiency before and after treatment with recombinant human growth hormone
10.3969/j.issn.1000-3606.2016.12.001
- VernacularTitle:生长激素缺乏症患儿重组人生长激素治疗前、后肾上腺皮质功能的变化
- Author:
Limin WANG
;
Yiming ZHAO
;
Xiumin LYU
;
Guimei LI
- Keywords:
growth hormone deficiency;
recombinant human growth hormone;
adrenal cortical function
- From:
Journal of Clinical Pediatrics
2016;34(12):881-885
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of adrenal cortical function in children with growth hormone deficiency before and after treatment with recombinant human growth hormone. Methods Seventy-two children diagnosed with GHD who received rhGH treatment for no less than 6 month were included, among whom there were 32 children who were accompanied with adrenal cortical hormone (ACTH) deficiency. The changes of fasting plasma cortisol (COR) and ACTH levels before and 3 and 6 months after treatment with rhGH were retrospectively analyzed. Results Thirty-two children with ACTH deficiency were treated with rhGH after COR level reached normal by the supplementing exogenous hydrocortisone. There was negative correlation between COR level before treatment and the HC dose that make the COR reach normal lowest limit level (r?=?-0.899, P??0.05). The level of COR was obviously decreased after treatment with rhGH, and there was statistical difference compared with that before treatment (P?
