Correlation of asthma with ADAM 33 SNP in Uygur and Han children in Urumqi
10.3969/j.issn.1000-3606.2016.12.011
- VernacularTitle:乌鲁木齐地区维、汉族儿童哮喘与ADAM33基因多态性的相关性
- Author:
Jianrong WANG
;
Yingjie WU
;
Muzapae DUOLIKUN
- Keywords:
ADAM33 gene;
loci polymorphism;
asthma;
Uygur;
child
- From:
Journal of Clinical Pediatrics
2016;34(12):926-929
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between ADAM33 SNP and asthma in Uygur and Han children in Urumqi. Methods Eighty-six Uygur and 111 Han children aged 3-15 years old who had asthma and lived in Urumqi were included. Meanwhile 56 Uygur and 64 Han healthy children were also included as control group. Genotyping of single nucleotide polymorphism (SNP) of V4 and T2 loci in ADAM 33 gene was performed by PCR, and verifications was made. Results There were statistical differences of V4 and T2 loci in ADAM 33 gene among asthma group and control group (P all??0.05) while there were differences in Uygur children (P all
