Clinical features and treatment of autoimmune hemolytic anemia in 29 children

VernacularTitle:儿童自身免疫性溶血性贫血29例临床特点和治疗分析
Author: Fei XIE ; Lin ZHOU ; Bin CAI ; Lei LEI ; Jinjin JIANG ; Ruohua CHEN
Keywords: autoimmune hemolytic anemia; jaundice; Coombs test; child
From: Journal of Clinical Pediatrics 2016;34(12):930-932
CountryChina
Language:Chinese
Abstract: Objective To analyze the etiology and treatment of autoimmune hemolytic anemia. Methods The clinical data of 29 children with autoimmune hemolytic anemia during January 2013 to December 2015 were retrospectively analyzed. Results In 29 children, 10 cases were idiopathic 19 cases were secondary and 11 cases occurred after infections. The main clinical manifestations were pallor, jaundice, dark urine, and hepatosplenomegaly. 21 cases were Coombs test positive. In 29 children, 22 cases had a good response to adrenocortical hormone therapy while in 7 cases which had not response to adrenocortical hormone, good efficacy was achived after combined with the gamma globulin treatment. Conclusions The first line drug for autoimmune hemolytic anemia treatment is adrenocortical hormone. The gamma globulin can improve the efficacy.