Analysis on significance of HBV envelope large protein and its correlation with virus replication in patients with chronic hepatitis B
10.3969/j.issn.1673-4130.2016.23.012
- VernacularTitle:乙型肝炎病毒外膜大蛋白意义分析及与慢性乙型肝炎患者病毒复制的相关性研究
- Author:
Lingfan YIN
;
Jingyun TANG
;
Rimei ZHANG
;
Yun RAN
;
Jianhui XIONG
- Keywords:
hepatitis B virus envelope large protein;
chronic hepatitis B;
hepatitis B virus E antigen;
correlation
- From:
International Journal of Laboratory Medicine
2016;37(23):3271-3273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship among serum hepatitis B virus (HBV ) envelope large protein (HBV‐LP ) , HBV‐DNA and HBV marker(HBV‐M ) for investigating the clinical significance of HBV‐LP to reflect the HBV in vivo replication in the patients with HBV infection .Methods Total 540 cases of chronic HBV infection treated in the Longgang District Hospital of Traditional Chinese Medicine from April 2013 to September 2015 were selected .The real‐time fluorescence quantitative PCR meth‐od was used to detect serum HBV‐DNA ,HBV‐LP and HBV‐M were detected by the enzyme linked immunosorbent assay (ELISA) . The correlation among HBV‐LP ,HBV‐M and HBV‐DNA were analyzed .Results The positive rate of HBV‐LP in HBeAg‐positive patients was 96 .39% ,and which of HBV‐DNA was 93 .33% ,there was no statistically significant difference between them (P>0 .05);The serum HBV‐LP level was positively related with the logarithmic value of HBV‐DNA copies ;the positive rate of HBV‐LP in HBeAg‐negative patients was 63 .33% ,and which of HBV‐DNA was 51 .11% ,the difference between them was statistically significant(P<0 .05) .Conclusion HBV‐LP can effectively reflect the HBV in vivo replication in the patients with chronic hepatitis B and its sensitivity is higher than that of HBeAg ,HBV‐LP can even more reflect the HBV in vivo replication status in patients with HBeAg‐negative chronic hepatitis B .
