Mechanism of CCL2/MCP-1 in its relevant diseases
10.3969/j.issn.1001-1978.2016.12.002
- VernacularTitle:CCL2／MCP-1在其相关疾病的机制研究
- Author:
Yina JIANG
;
Naihong CHEN
- Keywords:
chemokines;
CCL2;
receptor;
monocytes;
immu-nity system;
cancer;
nerve disease
- From:
Chinese Pharmacological Bulletin
2016;32(12):1634-1638
- CountryChina
- Language:Chinese
-
Abstract:
Chemokine is a small protein which plays an impor-tant role in men's physiological function.It has chemotactic ac-tivity and is often secreted by immune cells and glial cells like microglia or astrocytes.Through the effect of chemokine recep-tors on target cells,various immune cells can achieve directional migration and play an important role in the diseases related with immunity and inflammation.CCL2,also known as monocyte chemotactic protein-1 (MCP-1 ),is one member of chemokine CC subfamily (βsubfamily).It can chemokine monocytes, macrophages and T lymphocytes to affect their phagocytosis func-tion and produce antibodies to combat invading microorganisms. In recent years,it has been found that CCL2 plays a key role in the occurrence and development of the problems concerning cen-tral nervous system and immune system as well as cancer, AIDS,leukemia,diabetes and other diseases.This thesis is to give an elaboration on the latest research on CCL2 and the rele-vant diseases.
