Lipid metabolism and mechanism research of piperine on glucose metabolism of model rats with insulin resistance syndrome
10.3969/j.issn.1001-1978.2016.12.021
- VernacularTitle:胡椒碱对胰岛素抵抗综合征模型大鼠脂代谢及作用机制的研究
- Author:
Nali SONG
;
Chunping WAN
;
Zhenjie LI
;
Zhaorigetu BAO
- Keywords:
piperine;
insulin resistance syndrome;
fat metablism;
TNF-α;
leptin;
TG
- From:
Chinese Pharmacological Bulletin
2016;32(12):1746-1749
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of piperine (PIP)on triglycerides(TG),free fatty acid(FFA), tumor necrosis factor-α(TNF-α)and leptin of model rats with insulin resistance syndrome(IRS).Methods By feeding rats with high-fat,high-glucose and high-salt diet,IRS model rats were established.Triglycer-ides(TG)was observed dynamically every 4 weeks, treating on the 4th weeks and 8 weeks continuously. TG (method of GOD-POD),FFA (method of colori-metric),TNF-αand leptin (method of ELISA)were measured.Results After 8 weeks treatment,the level of TG,FFA,TNF-αand leptin in PIP group decreased obviously,while it increased in model group signifi-cantly.Conclusions PIP could reduce TG and FFA and improve abnormal lipid metabolism of model rats with IRS significantly.Perhaps the mechanism is relat-ed with the down-regulation of cytokine TNF-αand leptin.
