Advance in Exercise for Bone Metabolism Pathways (review)
10.3969/j.issn.1006-9771.2016.12.013
- VernacularTitle:运动对骨代谢信号通路影响的研究进展
- Author:
Xiaoyang TONG
;
Lingli ZHANG
;
Jianmin GUO
;
Yu YUAN
;
Jun ZOU
- Keywords:
exercise;
mechanical stress;
bone metabolism pathway;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(12):1425-1429
- CountryChina
- Language:Chinese
-
Abstract:
The process of exercise regulating bone metabolism is complicated, which involves a number of signaling pathways. A large number of studies in vitro have indicated that mechanical stress regulates bone metabolism by Wnt, bone morphogenetic protein (BMP), and osteoprotegerin (OPG)/receptor activator of NF-κB ligand (RANKL)/receptor activator of NF-κB (RANK) signaling pathways. Both the in-tensity and frequency of mechanical stress have varing impact on bone tissue and cells. Plenty of studies in vivo also have shown that exer-cise regulates bone metabolism by key factors in bone metabolism signaling pathways. This paper reviewed the effects of exercise on bone metabolism pathways and their mechanisms.
