The study on SIRT4 gene expression and prognostic factors in osteosarcoma
10.11904/j.issn.1002-3070.2016.06.005
- VernacularTitle:SIRT4基因表达与骨肉瘤预后因素相关性研究
- Author:
Qingyu SHI
;
Liancai LI
;
Wei MAI
;
Junjie BAO
;
Chunyu SONG
;
Guofan QU
- Keywords:
Osteosarcoma;
Immunohistochemistry;
SIRT4 proteinS;
urvival analysis
- From:
Practical Oncology Journal
2016;30(6):502-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore SIRT4 gene expression in tumor tissue and investigate the clinicol-pathological features in osteosarcoma .Methods In this study ,SIRT4 protein expression was detected in 106 os-teosarcoma tissues and 36 paired neighboring non -tumorous tissues by immunohistochemistry and determined the correlation between the SIRT 4 expression and the clinicopathological features .Results SIRT4 protein was dra-matically decreased in osteosarcoma cells compared with neighboring non -tumorous bone cells .The low expres-sion of SIRT4 was notably associated with a poor overall survival and disease -free survival in osteosarcoma pa-tients.By using univariate and multivariate analyses ,we confirmed that the increased SIRT 4 expression was an in-dependent factor in predicting better prognosis for patients .Conclu is on SIRT4 expression might be an inde-pendent biomarker for prognostic evaluation of osteosarcoma .
