Effects of SOD,NO,TNF-α and hs-CRP on atherosclerosis in patients with hypertension complicating diabetes mellitus
10.3969/j.issn.1673-4130.2016.23.017
- VernacularTitle:SOD、NO、TNF-α和hs-CRP对高血压合并糖尿病患者动脉粥样硬化的影响
- Author:
Jing PENG
- Keywords:
SOD;
NO;
TNF-α;
hs-CRP;
hypertension complicating diabetes mellitus;
atherosclerosis
- From:
International Journal of Laboratory Medicine
2016;37(23):3285-3287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of SOD ,NO ,TNF‐αand hs‐CRP on atherosclerosis in the patients with hyperten‐sion complicating diabetes mellitus (DM ) .Methods One hundred and thirty‐four inpatients in our hospital from January 2010 to January 2016 were selected ,including 45 cases of hypertension ,44 cases of type 2 diabetes Mellitus(T2DM ) and 45 cases of hyper‐tension complicating T2DM .IMT and serum SOD ,NO ,TNF‐α and hs‐CRP levels were detected .Contemporaneous 45 individuals undergoing healthy physical examination were selected as the healthy control group for conducting the contrastve analysis . Results The SOD and NO levels in the hypertension complicating T 2DM group were significantly lower thin the healthy control group ,hypertension group and T2DM group ,the difference had statistical significance (P<0 .05) .The levels of SOD ,NO ,TNF‐α, hs‐CRP and IMT had no statistical significance between the hypertension group and T 2DM group(P>0 .05) .IMT was positively correlated with TNF‐αand hs‐CRP(r=0 .636 ,0 .664 ,P< 0 .05)and negatively correlated with NO and SOD (r= -0 .586 ,0 .648 ,P<0 .05) .Conclusion Evaluating the change of SOD ,NO and TNF‐αand hs‐CRP levels can further investigate its occurrence mechanism and also has certain significance to the prevention and treatment of vascular injury chronic diseases such as hypertension and TM .
