Effects of tanshinone IIA on cardiac monophasic action potential in acute cerebral ischemia rats

VernacularTitle:丹参酮 IIA 对急性脑缺血大鼠心肌单相动作电位的影响
Author: Jing ZHAO ; Chen CHEN
Keywords: Tanshinone IIA; Cerebral ischemia; Action potential
From: Chinese Journal of Pathophysiology 2016;32(12):2291-2294
CountryChina
Language:Chinese
Abstract: AIM:To investigate the effects of tanshinone IIA ( Tan) on cardiac action potential in rats with a-cute cerebral ischemia (ACI).METHODS:ACI was established in rats accordingly .Animals were divided into 3 groups:sham group, ACI group, and ACI with Tan treatment group .The defect of neural function in each group was graded , elec-trocardiogram was measured , monophasic action potential was recorded , and the levels of cardiac troponin I ( cTnI ) and creatine kinase-MB ( CK-MB) were examined by commercially available kits .RESULTS:Compared with ACI group , Tan significantly decreased the scores of the defect of neural function , reduced the incidence and duration of the abnormalities in electrocardiogram , prolonged the effective refractory period , action potential duration at 50%repolarization and action po-tential duration at 90%repolarization, and inhibited the elevation of cTnI and CK-MB levels.CONCLUSION:Tan main-tains a stable heart rhythm in ACI rats , which may be related to its protective effect on ischemic myocardium .