Studies on activation,apoptosis and proliferation of NKT like cells in untreated HIV infected patients
10.3969/j.issn.1000-484X.2016.12.016
- VernacularTitle:未治疗HIV感染者NKT样细胞活化、凋亡和增殖的相关研究
- Author:
Tingting LIU
;
Xue ZHAO
;
Zining ZHANG
;
Yajing FU
;
Yongjun JIANG
- Keywords:
Human immunodeficiency virus;
Acquired immune deficiency syndrome;
NKT like cells
- From:
Chinese Journal of Immunology
2016;32(12):1797-1800
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the changes of the NKT like cells after HIV infected. Methods:We collected peripheral blood from 47 untreated HIV infected individuals and 31 healthy controls,and analyzed the expression of Annexin-V,Ki-67,HLA-DR and other surface molecules in NKT like cells by flow cytometry. Results:The NKT like cell percentage of untreated HIV infected group was (3. 03±1. 61)%,the NKT like cell percentage of normal control group was (8. 30±7. 42)%,the percentage of NKT like cells in HIV infected individuals was significantly lower than the healthy controls ( P<0. 05 );the NKT like cell HLA-DR expression of untreated HIV infected group and normal control group were (5. 40±4. 10)% and (0. 89±0. 83)%,the NKT like cell Annexin-V expression of untreated HIV infected group and normal control group were (30. 21±13. 15)% and (5. 40±8. 05)% ,and the activation and apoptosis of NKT like cells was significantly higher after HIV infection compared with health individuals (P<0. 001,P<0. 01),the degree of activation was negatively correlated with CD4 count (r=-0. 885 7,P<0. 05);and the NKT like cell Ki-67 expression of untreated HIV infected group and normal control group were (11. 15±4. 76)% and (27. 63±18. 31)%,the proliferation ability was significantly lower after HIV infection compared with healthy controls(P<0. 05). Conclusion:HIV infection can significantly reduce the number of NKT like cells and its ability to proliferate,and increase its ability to activation and apoptosis.
