Relationship of immune response and immune imbalance mediated by Th17 cells and Treg cells with pulmonary function in COPD patients
10.3969/j.issn.1000-484X.2016.12.022
- VernacularTitle:COPD患者Th17细胞和 Treg细胞介导的免疫应答变化及免疫失衡与肺功能的关系研究
- Author:
Xiang MEN
;
Xiyu SHANG
- Keywords:
Chronic obstructive pulmonary disease;
Th17 cells;
Regulatory T cells;
Immune response;
Pulmonary function
- From:
Chinese Journal of Immunology
2016;32(12):1826-1829
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of the immune response and immune imbalance mediated by Th17 cells and Treg cells with pulmonary function in chronic obstructive pulmonary disease ( COPD) patients. Methods:90 COPD patients and 45 healthy volunteers with matched age and sex were selected. The COPD patients were divided into 2 groups according to the patient's condition. 45 healthy volunteers were collected as the control group. The lung function, Th17 cells, Treg cells and serum levels of in-flammatory cytokines were detected and compared. Results:In COPD patients, the FEV1%, FVC%, FEV1/FVC, Th17,Th17/Treg and inflammatory cytokines had increased in an order of moderate COPD, severe COPD and very severe COPD (P<0. 05). Treg had in-creased in an order of very severe COPD, severe COPD and moderate COPD ( P<0. 05 ) . FEV1%, FVC% and FEV1/FVC were negatively correlated with Th17 and Th17/Treg (P<0. 05). FEV1%, FVC% and FEV1/FVC were positively correlated with Treg (P<0. 05). Conclusion:Th17/Treg in peripheral blood of COPD patients is significantly correlated with the decrease of pulmonary func-tion.
