Effect of ursodeoxycholic acid on serum glucocholic acid, conjugated bile acid and sVCAM-1 in intrahepatic cholestasis of pregnancy
10.3969/j.issn.1005-1678.2016.11.011
- VernacularTitle:熊脱氧酸对妊娠合并肝内胆汁淤积综合症患者血清甘胆酸、结合胆汁酸及sVCAM－1水平的影响
- Author:
Liwen HU
;
Yinping HUANG
- Keywords:
ursodeoxycholic acid;
intrahepatic cholestasis of pregnancy;
cholyglycine;
conjugated bile acid;
sVCAM-1
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of ursodeoxycholic acid on serum levels of cholyglycine ( CG ) , conjugated bile acid ( CBA ) and soluble vascular cell adhesion molecules (sVCAM-1) in patients with intrahepatic cholestasis of pregnancy.Methods 56 patients who were diagnosed with intrahepatic cholestasis of pregnancy in our hospital were collected.All patients were randomly divided into experimental group and control group, 28 cases in each group. The control group were treated with dexamethasone, and the experimental group were treated with the treatment of ursodeoxycholic acid, after 7d of treatment, the serum levels of glucocholic acid , CBA, ALT, AST and sVCAM-1 were detected in all patients. Results After treatment, compared with control group, the serum CG,TBA,ALT,AST and sVCAM-1 levels were significantly lower in the experimental group,and the difference was statistically significant (P<0.05).Conclusion The ursodeoxycholic acid can significantly reduce the serum CG,TBA, ALT,AST and sVCAM-1 levels in patients with intrahepatic cholestasis of pregnancy,improve pregnancy outcome,with guidance significance for clinic.
