Effect of linezolid on procalcitonin in methicillin resistant staphylococcus infection

VernacularTitle:利奈唑胺对耐甲氧西林葡萄球菌感染患者降钙素原水平的影响
Author: Dan XU ; Chunrong WU ; Yuhui CUI
Keywords: linezolid; methicillin-resistance staphylococcus; procalcitonin
From: Chinese Journal of Biochemical Pharmaceutics 2016;36(11):88-90
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of linezolid on procalcitonin ( PCT) in the treatment of methicillin resistant staphylococcus ( MRS) infection.Methods 85 cases with MRS infection in our hospital were grouped, control group received vancomycin treatment, study group received linezolid, 2 weeks for 1 courses.Clinical effect were compared to explore the linezolid effect of PCT levels in patients with MRS infection.Results After treatment, defervescence time, bacterial clearance time, bacterial clearance rate and 48 hour mortality rate between two groups of patients had no significant difference.Compared with the control group, ICU treatment time in the study group was significantly lower ( P<0.05 ) .There was no significant difference in total effective rate between two groups.After treatment, the PCT and CRP in study group were lower than control group(P<0.05).Conclusion Linezolid has significant function to reduce the serum PCT level of patients with methicillin-resistant staphylococcus infection procalcitonin, which has better clinical curative effect.