Effect of radiotherapy combined with interventional therapy on vascular endothelial growth factor in patients with advanced cervical cancer
10.3969/j.issn.1005-1678.2016.11.033
- VernacularTitle:放疗联合介入治疗对中晚期宫颈癌患者血管内皮生长因子水平的影响
- Author:
Zhen LIU
;
Xiaoyan SU
;
Yan HU
;
Hai XU
- Keywords:
vascular endothelial growth factor;
middle-late cervical cancer;
interventional herapy;
radiation therapy
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):112-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of radiotherapy combined with interventional therapy on the changes of vascular endothelial growth factor (VEGF) in patients with advanced cervical cancer.Methods 62 cases of cervical cancer collected in the first people’s hospital of jingzhou city during January 2009 to February 2014 were randomly divided into two groups.The patients in group A were treated with radiotherapy, and the patients in group B were treated with radiotherapy combined with interventional therapy.The level of vascular endothelial growth factor in two groups after treatment was measured by enzyme-linked immunoassay.Results The level of vascular endothelial growth factor of group A was ( 241.77 ±85.86 )μg/L, significantly higher than ( 124.66 ±65.86 )μg/L of group B.The level of vascular endothelial growth factor was related with cervical deterioration degree, tumor stage and lymph nodes metastasis (P<0.05),not with the patient’s age, and the size of the tumors.The level of vascular endothelial growth can reflect the clinical efficacy of patients after therapy (P<0.05).Conclusion Vascular endothelial growth factor level has a close relationship with the degree of deterioration of cervical cancer, tumor staging, lymph node metastasis and the curative effect after the interventional therapy.
