Chinese Herbal Medicine and Liquid Wax for the Treatment of 30 Patients with Apatinib-induced Hand-foot Syndrome

VernacularTitle:药蜡治疗阿帕替尼所致手足综合征30例
Author: Youyan LIN ; Xiao FANG ; Xiaoqin LIN
Keywords: Application Therapy; Medicine wax; Tumor; Apatinib; Hand-foot syndrome
From: Shanghai Journal of Acupuncture and Moxibustion 2016;35(12):1462-1463
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical efficacy of Chinese herbal medicine and liquid wax in treating oral apatinib-induced hand-foot syndrome. Method Thirty patients with gastric or gastroesophageal junction adenocarcinoma, who had developed hand-foot syndrome after oral administration of apatinib for four weeks, with grade 0 in 3 cases, grade Ⅰ in 16 cases, grade Ⅱ in 9 cases and grade Ⅲ in 2 cases, were enrolled and treated by external application of Chinese herbal medicine and liquid wax on both hands and feet for three weeks. Result The 30 patients with hand-foot syndrome had grade 0 in 14 cases, grade Ⅰ in 14 cases, grade Ⅱ in 2 cases and grade Ⅲ in 0 case after treatment with Chinese herbal medicine and liquid wax. There was a definite therapeutic effect and a statistically significant difference (P<0.05). Conclusion External application of Chinese herbal medicine and liquid wax on both hands and feet for hand-foot syndrome not only has a definite therapeutic effect but is also an ideal means of prevention and treatment because of its noninvasive procedure and the high compliance of the patients.