Expression of AEG-1-1 gene in NSCLC and its clinical significance
10.3969/j.issn.1000-484X.2016.12.024
- VernacularTitle:AEG-1基因在NSCLC中的表达及其临床病理意义
- Author:
Jianhua GAO
;
Hua CAO
;
Xuan LI
;
Chunhua YU
;
Xiaodong SONG
- Keywords:
Non-small cell lung cancer;
Star-shaped limb mesenchymal cells up-regulated gene 1;
Gene expression;
Immuno-histochemical analysis
- From:
Chinese Journal of Immunology
2016;32(12):1833-1836
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of AEG-1 gene in NSCLC and its clinical significance. Methods:Selected our hospital cardiothoracic surgical resection of 83 cases of postoperative cancer tissues of NSCLC patients and 20 paracancer to study, immunohistochemical staining was used to detect the expression level of AEG-1 protein in two groups,the clinical and pathological of AEG-1 protein in patients with NSCLC was analyzed. Results:NSCLC tissues AEG-1 protein expression 46 cases ( 55. 42%) was sig-nificantly higher than 2 cases ( 10. 00%) of paracancer ( P<0. 05 ) . The high expression of AEG-1 protein in NSCLC tissue was significantly correlated with T stage,N stage and distant metastasis (P<0. 05),the relationship of AEG-1 between the age,sex,and dif-ferentiation degree of the patients was not significant ( P>0. 05 ) . AEG-1 high expression of NSCLC in patients with a median survival time of 15. 0 months was significantly lower than that of 19. 0 months (log-rankχ2=4. 119 P<0. 05,) in patients with low expression of AEG-1. Conclusion:AEG-1 gene expression has been up-regulated in NSCLC tissue,which was related to the clinical stage and distant metastasis of the patients.
