Mechanisms of Mitochondrial Dysfunction and its Influence on Cancer
10.3969/j.issn.1009-6604.2016.12.023
- VernacularTitle:线粒体功能障碍的原因及其对肿瘤作用的研究进展
- Author:
Qi LI
;
Bin CHEN
;
Zelian QIN
- Keywords:
Mitochondrion;
Gene;
Dysfunction;
Cancer
- From:
Chinese Journal of Minimally Invasive Surgery
2016;16(12):1150-1154
- CountryChina
- Language:Chinese
-
Abstract:
As a main cellular organelle for bioenergy production , the mitochondrion plays a pivotal role in aerobic respiration , substance metabolism , oxidative stress , apoptosis and calcium homeostasis .Increasingly studies have shown a close relationship between mitochondrial dysfunction and cancer .Mitochondrial metabolic disturbance , reactive oxygen species ( ROS ) increase, mitochondrial gene mutation , calcium overload and abnormal apoptosis can influence tumorigenesis , growth, invasiveness and metastasis of multiple tumors .We aimed to summarize the mechanisms and influences of mitochondrial dysfunction on cancer .
