Expression of IL-17A in Rheumatoid Arthritis Patients with Periodontal Disease
10.12007/j.issn.0258-4646.2016.12.013
- VernacularTitle:类风湿关节炎合并牙周疾病患者的IL-17A表达
- Author:
Lin ZHAO
;
Jingjing XU
;
Xiaofei WANG
;
Xiaoli ZHANG
- Keywords:
rheumatoid arthritis;
interleukin-17A;
chronic periodontal disease
- From:
Journal of China Medical University
2016;45(12):1115-1118
- CountryChina
- Language:Chinese
-
Abstract:
Objective The level of IL?17A in serum and gingival fluid was measured and the clinical significance was analyzed ,so as to under?stand the relationship between rheumatoid arthritis(RA)and periodontal lesions. Methods The study participants included 20 patients with RA and CP,20 patients with RA,20 patients with RA,20 patients with CP,and 20 healthy controls. All groups were balanced for age,sex,and smok?ing status. The expression levels of IL?17A in serum and gingival fluid of the four groups were determined by ELISA method. Results The level of serum IL?17A in RA+CP group,RA group,CP group and H group respectively 66.6±24.98,46.58±8.50,31.35±5.10,and 29.25±5.50 pg/mL;RA+CP group,RA group,CP group,H group of gingival fluid IL?17A levels were 25.71±5.1,19.97±4.95,18.85±5.36,and 15.38±4.36 pg/mL. The level of serum IL?17A and anti?CCP of patients in the RA+CP group had positive correlation(r=0.446,P<0.05),and the level of gingival fluid IL?17A and anti?CCP of patients in the RA+CP group had positive correlation(r=0.517,P<0.05). Compared with RA group,the visible clinical laboratory ESR,CRP,RF,anti?CCP,DAS28 and HAQ scores of RA+CP group were increased. Conclusion Rheumatoid arthritis may exacerbate the periodontal disease in patients with periodontal disease. On the other hand ,periodontal disease may also promote rheumatoid arthri?tis.
