Influence of amoxicillin and clavulanate potassium on postoperative infection and inflammatory indexes in emergency intestinal obstruction operation by relaxation suture
10.3969/j.issn.1005-1678.2016.11.014
- VernacularTitle:阿莫西林克拉维酸钾对急诊肠梗阻手术减张缝合患者术后感染及炎症指标的影响
- Author:
Yongyang YU
;
Yun HUANG
;
Zhaohui LIU
;
Fuxing ZHANG
- Keywords:
amoxicillin and clavulanate potassium;
emergency intestinal obstruction operation;
relaxation suture;
infection related indexes
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):53-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence situation of amoxicillin and clavulanate potassium for the postoperative infection and inflammatory indexes of patients with emergency intestinal obstruction operation by relaxation suture .Methods 80 patients with emergency intestinal obstruction operation by relaxation suture in department of general gurgery of our hospital from April 2014 to April 2016 were randomly divided into control group and observation group with 40 cases in each group, the control group were treated with routine treatment, the observation group were treated with amoxicillin and clavulanate potassium on the treatment of control group, then the postoperative infection rates, inflammatory related indexes before and after the treatment of two groups were compared.Results The postoperative infection rate of observation group was 5.00%,and it was obviously lower than the 17.50% of control group, the difference was significant(P<0.05); the serum inflammatory related indexes of two groups before the treatment were compared,the differences were not significant ;the serum anti-inflammatory indexes interleukin-4(IL-4), IL-10, IL-13 and pro-inflammatory indexes tumor necrosis factor-α(TNF-α), IL-6 at 1st, 2nd and 5th day after the treatment were all lower than those of control group,the pro-inflammatory index IL-2 were higher than those of control group, the differences were all significant(P<0.05).Conclusion The amoxicillin and clavulanate potassium can reduce the postoperative infection of patients with emergency intestinal obstruction operation by relaxation suture , and its control role for the related inflammatory indexes is better, so its application value is higher and is worthy of clinical promotion.
