Effects of alprostadil injection on IL-6, IL-8, TNF-αand insulin resistance in patients with diabetes mellitus
10.3969/j.issn.1005-1678.2016.11.020
- VernacularTitle:前列地尔注射液对糖尿病患者血清及胰岛素抵抗的影响
- Author:
Dongmei GAO
;
Guoying HU
- Keywords:
alprostadil injection;
diabetes mellitus;
inflammatory factor;
insulin
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):71-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of alprostadil injection on IL-6, IL-8, TNF-αand insulin resistance in diabetic patients.Methods 90 patients with diabetes mellitus in our hospital from January 2014 to May 2016 were selected,and randomly divided into observation group and control group,45 cases in each groups.The control group received conventional western medicine , the observation group was treated with alprostadil injection.The levels of serum IL-6, IL-8, TNF-α, insulin and insulin resistance index were compared before and after treatment in both two groups. Results After treatment,the total effective rate of treatment group was 91.11%,which was significantly higher than the control group 71.11%( P<0.05).Before treatment,the levels of IL-6,IL-8,TNF-α,insulin and insulin resistance index of two groups were had no statistical significance,after treatment,the levels of IL-6,IL-8,TNF-α,insulin and insulin resistance index were decreased in both groups,and the observation group was significantly lower than the control group,the difference was statistically significant (P<0.05).Conclusion The alprostadil injection can significantly reduce the levels of IL-6,IL-8,TNF-α,and control the level of blood glucose,reduce the effect of insulin resistance.
