Regulatory Mechanism and Clinical Application of MicroRNAs in Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2016.12.012
- VernacularTitle:MicroRNA 在炎症性肠病中的调控机制和临床应用
- Author:
Jiazheng WANG
;
Yingwei CHEN
- Keywords:
Colitis,Ulcerative;
Crohn Disease;
MicroRNAs;
Intestinal Immune System;
Therapy
- From:
Chinese Journal of Gastroenterology
2016;21(12):748-751
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a chronic nonspecific intestinal inflammatory disease and its etiology is not yet clarified. MicroRNAs( miRNAs)is a class of endogenous noncoding RNA that exerts post-transcriptional regulation on gene expression. Studies found that miRNAs is involved in the regulation of intestinal mucosal barrier and mucosal immune system;abnormal expression of miRNAs is associated with the occurrence of IBD. This article reviewed the regulatory mechanism and clinical application of miRNAs in IBD.
