Metabolic Mechanism of Copper and its Toxic Effect on Liver
10.3969/j.issn.1008-7125.2016.12.016
- VernacularTitle:铜代谢机制及其对肝脏的毒性作用
- Author:
Liangliang ZHANG
;
Nan CHENG
;
Xun WANG
- Keywords:
Copper;
Metabolism;
Liver;
Toxicity;
Apoptosis
- From:
Chinese Journal of Gastroenterology
2016;21(12):762-764
- CountryChina
- Language:Chinese
-
Abstract:
Copper is an essential trace element and plays an important role in the synthesis and function of many metabolic enzymes. However,it may be toxic when copper is overloaded. Numerous studies have been conducted on copper metabolism,especially the toxicity on liver;but systemic review is rare. This article is a systemic review on metabolism, mechanism of toxic effect,liver disease related to overloading of copper,and illustrates the effect of copper on liver ultra structure,oxidative stress,mitochondrial function,cell cycle and apoptosis.
