Th17/Treg balance in inflammatory bowel disease
10.3760/cma.j.issn.1673-4408.2017.01.014
- VernacularTitle:Th17/Treg平衡在炎症性肠病中的意义
- Author:
Liyun WANG
;
Jing GUO
- Keywords:
Inflammatory bowel disease;
Th17/Treg balance;
Intestinal homeostasis
- From:
International Journal of Pediatrics
2017;44(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD) is characterized by chronic non-specific inflammatory dis ease.The inflammation caused by abnormal immune response in intestinal mucosa exerts an important role in the pathogenesis of IBD.T helper 17 cells(Th17)are involved in the development of chronic inflammation and auto immune disease,whereas regulatory T cells can inhibit the function of autoimmune,and thus the balance of Th17/Treg balance plays an important role in intestinal homeostasis.Various strategies can be done to modulate Th17/Treg balance,such as antigen-presenting cells,microoganisms,some key molecules,natural compounds,proving a promising therapeutic method for IBD.
