Optical Coherence Tomography-based Diagnosis of Polypoidal Choroidal Vasculopathy in Korean Patients.
10.3341/kjo.2016.30.3.198
- Author:
Young Suk CHANG
1
;
Jae Hui KIM
;
Jong Woo KIM
;
Tae Gon LEE
;
Chul Gu KIM
Author Information
1. Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea.
- Publication Type:Observational Study ; Original Article
- Keywords:
Choroidal neovascularization;
Diagnosis;
Macular degeneration;
Optical coherence tomography;
Polypoidal choroidal vasculopathy
- MeSH:
Aged;
Choroid/blood supply/*diagnostic imaging;
Choroid Diseases/*diagnosis/epidemiology/physiopathology;
Diagnosis, Differential;
Female;
Fluorescein Angiography;
Follow-Up Studies;
Fundus Oculi;
Humans;
Incidence;
Male;
Republic of Korea/epidemiology;
Retrospective Studies;
Tomography, Optical Coherence/*methods;
Visual Acuity
- From:Korean Journal of Ophthalmology
2016;30(3):198-205
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the efficacy of an optical coherence tomography (OCT)-based diagnosis of polypoidal choroidal vasculopathy (PCV) in Korean patients. METHODS: This retrospective, observational case series included 263 eyes of 263 patients (147 eyes with PCV and 116 eyes with typical exudative, age-related macular degeneration [AMD]) who had been diagnosed with treatment naïve exudative AMD. Eyes with three or more of the following OCT findings were diagnosed with PCV: multiple retinal pigment epithelial detachment (RPED), a sharp RPED peak, an RPED notch, a hyporeflective lumen representing polyps, and hyperreflective intraretinal hard exudates. The OCT-based diagnosis was compared with the gold-standard indocyanine green angiography-based method. The sensitivity and specificity of the OCT-based diagnosis was also estimated. An additional analysis was performed using a choroidal thickness criterion. Eyes with a subfoveal choroidal thickness greater than 300 µm were also diagnosed with PCV despite having only two OCT features. RESULTS: In eyes with PCV, three or more OCT features were observed in 126 of 147 eyes (85.7%), and the incidence of typical exudative AMD was 16 of 116 eyes (13.8%). The sensitivity and specificity of an OCT-based diagnosis were 85.7% and 86.2%, respectively. After applying the choroidal thickness criterion, the sensitivity increased from 85.7% to 89.8%, and the specificity decreased from 86.2% to 84.5%. CONCLUSIONS: The OCT-based diagnosis of PCV showed a high sensitivity and specificity in Korean patients. The addition of a choroidal thickness criterion improved the sensitivity of the method with a minimal decrease in its specificity.
