Advance research of Acetaminophen treatment for symptomatic patent ductus arteriosus in pretermature infant
10.3760/cma.j.issn.2095-428X.2017.02.019
- VernacularTitle:对乙酰氨基酚治疗早产儿症状性动脉导管未闭的研究进展
- Author:
Bo YANG
;
Xiangyu GAO
;
Mingyan HEI
- Keywords:
Acetaminophen;
Patent ductus arteriosus;
Infant,pretermature
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(2):152-155
- CountryChina
- Language:Chinese
-
Abstract:
Due to the dysontogenesis of the arterial duct wall and the abnormal secretion of prostaglandin,symptomatic patent ductus arteriosus is thus often presented in preterm infants.In the past,Indomethacin or Ibuprofen (cyclooxygenase inhibitor) was always chosen to be the interventional medication.While in recent years,Acetaminophen (prostaglandin synthetase inhibitor) has become another therapeutic option for symptomatic patent ductus arteriosus with similar efficacy but less adverse events.The latest research of the mechanism,the therapeutic strategy of time,mode,dosage and duration,the efficacy and the adverse events of Acetaminophen were reviewed.
