The role of vitamin D in rheumatoid arthritis
10.3760/cma.j.issn.1008-1372.2016.11.049
- VernacularTitle:维生素D在类风湿关节炎中的作用及其研究进展
- Author:
Ronghua XIE
;
Zhaohui ZHENG
;
Ping ZHU
- Keywords:
Vitamin D;
Vitamin D deficiency;
Arthritis,rheumatoid;
Review
- From:
Journal of Chinese Physician
2016;18(11):1744-1747
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D deficiency is highly prevalent in the general population including rheumatoid arthritis (RA) patients.Autocrine regulation of vitamin D modulates important immune response.Vitamin D deficiency may be involved in the pathogenesis of many autoimmune diseases including RA.Vitamin D regulates both the innate and adaptive immune responses.Vitamin D's effects on the innate immune system are mainly through the toll-like receptor and on the adaptive immune system through T cell differentiation,particularly the Helper T cell (Th) 17 response.As Thl7 cells are critical in the pathogenesis in RA,what effect will vitamin D deficiency lead to on the RA? Many data have indicated the relationship between vitamin D deficiency and RA disease activities,but not all the results are consistent.Here,we review the immune-modulatory roles of vitamin D and its effects on disease activity,osteoporosis and cardiovascular disease risk in RA.
