Analysis of the correlation between rs8444 polymorphisms located within LASS2-3′-UTR and susceptibility of bladder cancer
10.3969/j.issn.1000-8179.2017.03.240
- VernacularTitle:LASS2-3'-非翻译区rs8444单核苷酸多态性与膀胱癌易感性的相关性研究
- Author:
Yujin CHEN
;
Haifeng WANG
;
Ruping YAN
;
Changxing KE
;
Mingxia DING
;
Ting LUAN
;
Renchao ZOU
;
Jiansong WANG
- Keywords:
Homo sapiens longevity assurance homologue 2;
bladder cancer;
polymorphism;
single nucleotide
- From:
Chinese Journal of Clinical Oncology
2017;44(3):107-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between single nucleotide polymorphisms (SNPs) in Homo sapiens longevity assur-ance homologue 2 (LASS2) gene 3′-untranslated regions (UTR) and susceptibility of bladder cancer among residents of Yunnan, China. Methods:A total of 105 bladder cancer patients (bladder cancer group) and 100 nonbladder cancer patients (control group) were se-lected. PCR method and sequence for LASS2-3′-UTR were performed to identify the SNPs correlated with bladder cancer. The relation-ships between the LASS2-3′-UTR polymorphisms and bladder cancer risk were analyzed. Results:An SNP (rs8444) was identified in LASS2-3′-UTR, and the T/C allele frequencies and genotype distributions of rs8444 largely differed between the bladder cancer and control groups (χ2=10.267, P=0.006;χ2=10.634, P=0.001). Individuals that carry the rs8444 C allele or CC genotype had a remarkably lower risk of bladder cancer compared with those that carry the T allele or TT genotype (OR=0.489, 95%CI:0.309-0.772, P=0.002;OR=0.258, 95%CI:0.081-0.827, P=0.023). No significant correlations were observed between the T/C allele frequencies and genotype distri-butions of rs8444 and TNM stage, as well as histological grade and distant metastasis in bladder cancer (P>0.05). Conclusion: The rs8444 C allele or CC genotype located within LASS2-3′-UTR can lower the susceptibility of bladder cancer among the residents of Yun-nan, China. However, it is not associated with the TNM stage, histological grade, and distant metastasis.
